Ovarian & Endometrial cancer

Ovarian cancer is the fifth most common cancer in women. The prognosis of ovarian cancer is poor since women are commonly diagnosed with late stage disease i.e. stage III/IV, for which 5-year survival rates are around 27% and 16%. Better non-invasive tests for early detection of ovarian cancer are urgently required to reduce mortality due to this disease. Our group has a major interest in identifying novel biomarkers and factors that could be used for risk stratification/ screening and on that basis we have set up several internal studies and external collaborations.

Projects:

EPI-FEM-CARE Ovarian Cancer Epigenetics

Investigators	Martin Widschwendter, Shazia Anjum, Alison Jones, A Wong (UCL); David Cibula (Charles University Hospital, Prague, Czech Republic), Ian Jacobs, Usha Menon, (UCL)
Funders	EU FP7

Discovery of novel cancer serum biomarkers based on aberrant post translational modifications of O-glycoproteins (O-PTM-Biomarkers) and their application to early detection of cancer

Investigators	Joy Burchell, Joyce Taylor-Papadimitriou (KCL, London), Henrik Clausen (University of Copenhagen, Copenhagen); Bruce Acres (Transgene, Strasbourg, Germany); Tilo Schwientek (University of Cologne, Cologne, Germany)
Funders	EU FP7

Perfomance of HE4/HE4 and CA72.4 combined with CA125/ROC algorithm in screening for ovarian cancer (1)

Investigators	Usha Menon, Aleksandra Gentry-Maharaj (UCL), Steve Skates (MGH, USA), Ian Jacobs (UCL, UNSW)
Funders	CRUK Eve Appeal

Proteomic Analysis of the Human Serum Proteome for Population Screening, Diagnosis and Biomarker Discovery

Investigators	Rainer Cramer (Reading University), Mike Waterfield (UCL), Alex Gammerman (RHUL), Usha Menon (UCL), Ian Jacobs (UCL)
Funders	MRC

Risk Stratification, Early Detection and Diagnosis of Ovarian Cancer (PROMISE 2016)

Investigators	Ian Jacobs (UCL), Simon Gayther, Susan Ramus (USC, Los Angeles, USA); Alexey Zaikin, Usha Menon, John Timms (UCL); Steve Skates (MGH and Harvard Medical School, Boston, USA); Antonis Antoniou (Cambridge University, UK)
Funders	CRUK Eve Appeal

ROCkeTS - Refining Ovarian Cancer Test Accuracy Scores

Investigators	Sudha Sundar (Birmingham Univ), Usha Menon, Aleksandra Gentry-Maharaj (UCL)
Funders	NIHR

Performance evaluation of an algorithm for early detection of ovarian cancer based on a panel of serum biomarkers measured annually

Investigators	Robert Bast, Keith Baggerly, Zheng Zhang (MD Anderson Cancer Centre, Houston, Texas, USA); Steven Skates (Harvard, Boston, USA)
Funders	CPRIT grant “Texas Cancer Diagnostics Pipeline Consortium”

Validation of serum marker decision rule using CA125, HE4, MSLN, and MMP7 to select women for surgical consult or additional testing

Investigators	Nicole Urban (Fred Hutch Cancer Centre, Seattle, USA), Usha Menon (UCL), Ian Jacobs (UCL)
Funders	Spore grant NIH, USA

Validation of the novel multimarker assay for early detection of ovarian cancer

Investigators	Anna Lokshin (University of Pittsburgh, USA), Usha Menon (UCL), Ian Jacobs (UCL)
Funders	RO1, NIH, USA

Blood glycoprotein biomarkers for early detection or differential diagnosis of ovarian cancer

Investigators	Assoc Prof Michelle Hill, Prof Usha Menon (UCL), Dr Aleksandra Gentry-Maharaj, Dr Sophia Apostolidou (UCL)
Funders	OCRF

Radiomics Machine Learning Models for Diagnostics, Early detection and Prognostics in Ovarian Cancer Using Transvaginal Ultrasound Imaging

Investigators	Prof Eric Aboagye (Imperial College), Mr Kristofer Linton-Reid (Imperial College), Prof Usha Menon (UCL), Dr Andy Ryan (UCL), Dr Aleksandra Gentry-Maharaj (UCL), Dr Sophia Apostolidou (UCL)
Funders	Imperial College London

Evaluation of an ovarian cancer screening assay - nested case control study within UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)

Commercial collaboration

Implementing a Multivariate Index Assay for the Earlier Detection of Ovarian Cancer

Investigators:

Assoc Prof Carlos Salomon (University of Queensland), Prof Usha Menon (UCL), Prof Gregory Rice (University of Queensland), Prof Sunil Lakhani (University of Queensland), Prof Amanda Barnard (Australian National University), Assoc Prof Hanna Suominen (Australian National University), Assoc Prof Mahesh Choolani (National University of Singapore), Dr Aleksandra Gentry-Maharaj (UCL), Dr Sophia Apostolidou (UCL)

Funder:

NHMRC